Journal of Ultrasound in Medicine, Vol 8, Issue 2 59-63, Copyright © 1989 by American Institute of Ultrasound in Medicine
The prenatal sonographic features of Noonan's syndrome
B. R. Benacerraf, M. F. Greene and L. B. Holmes
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
The sonographic findings in four infants with Noonan's syndrome are
described. All four fetuses had cystic hygromata located laterally along
the cervical spine and normal karyotypes. Three of the four pregnancies
were complicated by polyhydramnios and those three fetuses had associated
pleural effusions. One fetus developed frank hydrops and did not survive, a
clinical course that appears to be part of the clinical spectrum of
Noonan's syndrome. The diagnosis of Noonan's syndrome was given serious
consideration prenatally based on the sonographic findings and normal
karyotype and confirmed at birth in all four cases. Three of the infants
survived.
