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Sonography of Biopsy-Proven Langerhans Cell Histiocytosis in Lymph Nodes of the Neck

Departments of Radiology (E.T.P., S.S., H.Y.S., Y.H.L., H.S.S.) and Pathology (B.K.S.), Korea University College of Medicine, Seoul, Korea.

Address correspondence to Sang-il Suh, MD, Department of Radiology, Korea University Guro Hospital, 97 Guro Dong, Guro-Gu, Seoul 152-703, Korea. E-mail: ssickh{at}korea.ac.kr

Objective. The purpose of this series is to describe the sonographic findings of lymph nodes of the neck involved by Langerhans cell histiocytosis (LCH). Methods. We reviewed and interpreted available images of lymph nodes in patients with cervical lymphadenopathies involved by LCH for the past decade. In all patients, each abnormal lymph node was pathologically confirmed by the use of a sonographically guided core needle biopsy or an incisional biopsy. Results. We characterized 3 different kinds of imaging findings for cervical lymph nodes involved by LCH: (1) a lymphomalike lesion, (2) a lesion similar to reactive lymphadenopathy, and (3) a cystic lymph node. Conclusions. There was no specific imaging finding to diagnose lymphadenopathy involved by LCH. In our study, we characterized 3 different imaging patterns of lymph node involvement by LCH. This study represents an initial step to organize specific findings for LCH.

Key Words: cervical lymph node • Langerhans cell histiocytosis • sonography

Abbreviations: CT, computed tomography • LCH, Langerhans cell histiocytosis