JUM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Kudla, M. J.
Right arrow Articles by Arslan, A. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kudla, M. J.
Right arrow Articles by Arslan, A. A.
© 2008 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 27:425-433 • 0278-4297

Technical Advance

Spherical Tissue Sampling in 3-Dimensional Power Doppler Angiography

A New Approach for Evaluation of Ovarian Tumors

Marek J. Kudla, MD, Ilan E. Timor-Tritsch, MD, Joanie Mayer Hope, MD, Ana Monteagudo, MD, Dorota Popiolek, MD, Susan Monda, MS, RDMS, Catherine J. Lee, MD and Alan A. Arslan, MD

Department of Obstetrics and Gynecology, Medical University of Silesia, Katowice, Poland (M.J.K.); and Departments of Obstetrics and Gynecology (I.E.T.-T., J.M.H., A.M., S.M., C.J.L., A.A.A.) and Pathology (D.P.), New York University School of Medicine, New York, New York USA.

Address correspondence to Marek J. Kudla MD, Department of Obstetrics and Gynecology, Medical University of Silesia, Medykow 14, 40-780 Katowice, Poland. E-mail: marekkudla{at}hotmail.com

Objective. The purpose of this study was to evaluate the usefulness of virtual spherical tissue sampling using 3-dimensional (3D) ultrasound power Doppler angiography to enhance differentiation between normal and pathologic ovaries. Methods. Twenty-seven cases with ovarian tumors were analyzed: 14 with invasive cancers and 13 with borderline tumors confirmed by surgery. The control subjects consisted of 53 healthy ovulating women. Ultrasound scans were done, and 3D volumes were analyzed with 3-/4-dimensional software for personal computers based on 3D vascularity indices: the vascularization index, flow index, and vascularization-flow index. A virtual spherical tissue sample of 1 cm3 was taken from the place of the highest vessel density contained completely within the contours of the ovary. Calculations for the whole solid volume were done for comparison. Results. Vascularity indices for both 1-cm3 spherical samples and whole dense parts of the ovaries were compared in the following groups: (1) ovarian tumors versus controls, (2) normal ovaries in the proliferative versus secretory phase, (3) invasive cancers versus borderline tumors, (4) invasive cancers versus normal ovaries, and (5) borderline tumors versus normal ovaries. Spherical 1-cm3 sampling achieved a higher degree of discrimination between the groups compared with the whole solid-part approach. Conclusions. Spherical 1-cm3 sampling of ovarian tissue with 3D ultrasound power Doppler angiography is a sensitive and promising approach to differentiate between ovarian tumors and normal ovaries. It opens the possibility to implement objective computerized positioning, standardized comparison, and analysis of ovarian tumors.

Key Words: ovarian cancer • 3-dimensional power Doppler angiography • ultrasound

Abbreviations: FI, flow index • PDA, power Doppler angiography • 3D, 3-dimensional • 2D, 2-dimensional • VFI, vascularization-flow index • VI, vascularization index • VOCAL, virtual organ computer-aided analysis

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Institute of Ultrasound in Medicine.