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© 2008 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 27:225-231 • 0278-4297

Utility of Sonographically Guided Biopsy in Metabolically Suspected Recurrent Lymphoma

Michalle Soudack, MD, Rachel Bar Shalom, MD, Ora Israel, MD, Yehudith Ben-Arie, MD, Zofia Levy, BSc and Diana Gaitini, MD

Departments of Medical Imaging (M.S., D.G.), Nuclear Medicine (R.B.S., O.I.), and Pathology (Y.B.-A.), Rambam Medical Center, Haifa, Israel; and Bruce and Ruth Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel (M.S., R.B.S., O.I., Z.L., D.G.).

Address correspondence to Michalle Soudack, MD, Department of Medical Imaging, Rambam Medical Center, 8 Ha’aliya Hashniya, 31096 Haifa, Israel. E-mail: m_soudack{at}rambam.health.gov.il

Objective. The purpose of this study was to determine the diagnostic accuracy of sonographically guided biopsy of [18F]fluorodeoxyglucose (FDG)-avid foci on positron emission tomography (PET)/computed tomography (CT) in patients with lymphoma. Methods. We retrospectively reviewed the medical records of 56 patients with lymphoma (25 male and 31 female; mean age, 48.5 years; range, 22–80 years) who underwent sonographically guided biopsy of hypermetabolic FDG-avid foci precisely localized by PET/CT. Biopsies were performed up to 3 months after PET/CT. The accuracy of core biopsy was calculated and compared with clinical follow-up and histopathologic results of open biopsy. Results. Sixty-six sonographically guided biopsies were performed in the 56 patients. Histopathologic results were conclusive in 53 (80%) of 66. No complications occurred during or after the procedure. The overall sensitivity, specificity, positive predictive value, and accuracy for diagnosis of lymphoma were 100%, 95%, 97%, and 98%, respectively. Conclusions. Sonographically guided biopsy is a safe and effective means for investigating metabolically active lesions on FDG-PET/CT in patients with known lymphoma.

Key Words: computed tomography • interventional sonography • lymphoma • needle biopsy • positron emission tomography • sonography

Abbreviations: CT, computed tomography • FDG, [18F]fluorodeoxyglucose • PET, positron emission tomography • SGPB, sonographically guided percutaneous biopsy

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