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© 2008 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 27:209-214 • 0278-4297

Effect of Hyperbaric Oxygen on Flow-Mediated Vasodilation

An Ultrasound Study

Mutlu Saglam, MD, Ugur Bozlar, MD, Fatih Kantarci, MD, Hakan Ay, MD, Bilal Battal, MD and Unsal Coskun, MD

Departments of Radiology (M.S., U.B., B.B.) and Underwater and Hyperbaric Medicine (H.A.), Gulhane School of Medicine, Ankara, Turkey; Department of Radiology, Cerrahpasa School of Medicine, Istanbul, Turkey (F.K.); and Department of Radiology, Turkish Armed Forces Rehabilitation and Care Center, Ankara, Turkey (U.C.).

Address correspondence to Mutlu Saglam, MD, Department of Radiology, Gulhane School of Medicine, Gata Radyoloji Ad, Etlik, 06018 Ankara, Turkey. E-mail: mdsaglam{at}yahoo.com

Objective. The purpose of this study was to investigate the effect of hyperbaric oxygen (HBO) treatment on flow-mediated vasodilation (FMD) by ultrasound examination. Methods. We studied 14 young patients without cardiovascular problems who underwent HBO treatment. The indications for HBO treatment were osteomyelitis (n = 8), Crohn disease (n = 2), perianal abscesses (n = 2), lingual artery embolization (n = 1), and aseptic necrosis (n = 1). The ultrasound evaluation for FMD was performed before HBO treatment, after 1 session of HBO treatment, and after 10 sessions of HBO treatment. The right brachial artery FMD response was evaluated by the mean of the baseline right brachial artery diameter, absolute change in the diameter before and after cuff inflation/deflation, and percent change in the diameter. Results. Statistical analysis showed a significant change in the preinflation right brachial artery diameter before (mean ± SD, 3.6 ± 0.54 mm) and after (3.76 ± 0.56 mm) 10 sessions of HBO treatment (P < .05). The absolute changes in the right brachial artery diameter before and after cuff inflation/deflation (0.36 ± 0.2 mm before HBO treatment, 0.37 ± 0.22 mm after 1 session of HBO treatment, and 0.38 ± 0.21 mm after 10 sessions) and percent change in FMD (10% ± 5.8% before HBO treatment, 10.6% ± 7.5% after 1 session of HBO treatment, and 10.6% ± 7.7% after 10 sessions) after induction of a hyperemic response by cuff inflation were not statistically significant (P > .05). Conclusions. Hyperbaric oxygen treatment did not have an immediate effect on FMD (absolute change in the right brachial artery diameter after cuff inflation/deflation); however, the right brachial artery diameter increased after 10 sessions of HBO treatment. This may suggest chronic stress on the vascular endothelium after HBO.

Key Words: flow-mediated vasodilation • hyperbaric oxygen • ultrasound

Abbreviations: FMD, flow-mediated vasodilation • HBO, hyperbaric oxygen • NO, nitric oxide • NOS, nitric oxide synthase

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Copyright © 2008 by the American Institute of Ultrasound in Medicine.