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© 2007 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 26:1191-1199 • 0278-4297

Elastographic Evaluation of the Temporal Formation of Ethanol-Induced Hepatic Lesions

Preliminary In Vitro Results

Jinhua Shao, BS, Jing Bai, PhD, Ligang Cui, MD, Jinrui Wang, MD, Yifei Fu, MS, Ke Liu, BS and Shunyou Feng, BS

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China (J.S., J.B., Y.F., K.L.); Department of Diagnostic Ultrasound, Peking University Third Hospital, Beijing, China (L.C., J.W.); and Department of Diagnostic Ultrasound, Zunhua People’s Hospital, Hebei, China (S.F.).

Address correspondence to Jing Bai, PhD, Department of Biomedical Engineering, School of Medicine, Tsinghua University, 100084 Beijing, China; or Jinrui Wang, MD, Department of Diagnostic Ultrasound, Peking University Third Hospital, 100084 Beijing, China. E-mail: deabj{at}tsinghua.edu.cn, jinrui_wang{at}sina.com

Objective. The purpose of this study was to evaluate the temporal formation of ethanol-induced hepatic lesions using ultrasound elastography. Methods. An in vitro porcine liver was used as the specimen, and 4 lesions were created by injection of 2 mL of ethanol. After the ethanol injection, freehand elastography of the lesion from an identical scan plane was obtained during a time series (with an interval of {approx}30 seconds in the first 2 minutes and 1 minute afterward) using a real-time ultrasound scanner. The area of the lesion in the elastographic sequences was calculated to depict the temporal formation of the lesion. Results. The ethanol-induced lesion on elastography appeared as a low-strain region whose boundary was clear and irregular. The elastographic sequences obtained after the ethanol injection showed that the lesion formed quickly in the first 2 minutes and then changed little in shape. The area of the lesion grew notably in the first 2 minutes after ethanol injection, and then it reached a plateau of about 0.7 cm2. Conclusions. Ultrasound elastography is capable of monitoring the temporal formation of ethanol-induced lesions and is a potential imaging modality to evaluate the response of percutaneous ethanol injection therapy.

Key Words: elastography • ethanol diffusion • hepatic lesion • temporal formation • ultrasound

Abbreviations: HCC, hepatocellular carcinoma • PEI, percutaneous ethanol injection • RF, radio frequency • ROI, region of interest • SNR, signal-to-noise ratio • URI, ultrasound research interface

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Copyright © 2007 by the American Institute of Ultrasound in Medicine.