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© 2007 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 26:1761-1765 • 0278-4297

Primary Thyroid Lymphoma

Role of Ultrasound-Guided Needle Biopsy

Jin Young Kwak, MD, Eun-Kyung Kim, MD, Kyung Hee Ko, MD, Woo Ik Yang, MD, Min Jung Kim, MD, Eun Ju Son, MD, Ki Keun Oh, MD and Ki Whang Kim, MD

Department of Diagnostic Radiology, Research Institute of Radiological Science (J.Y.K., E.-K.K., M.J.K., E.J.S., K.K.O., K.W.K.), and Department of Pathology (W.I.Y.), Yonsei University College of Medicine, Seoul, Korea; and Department of Diagnostic Radiology, Cha General Hospital, College of Medicine, Pochon Cha University, Seoul, Korea (K.H.K.).

Address correspondence to Eun-Kyung Kim, MD, Department of Diagnostic Radiology, Yonsei University College of Medicine, 250 Seongsanno, 134 Sinchondong, Seodaemungu, Seoul 120–752, Korea., E-mail: ekkim{at}yumc.yonsei.ac.kr

Objective. The purpose of this study was to describe the sonographic findings of primary thyroid lymphoma and evaluate the role of ultrasound-guided biopsy in diagnosing thyroid lymphoma. Methods. This study included 6 patients (age range, 56–72 years; mean, 62.5 years). We searched the database of our institution and retrospectively collected data on the thyroid lymphomas that were confirmed pathologically. All of the sonograms and medical records were reviewed retrospectively. Results. All 6 patients had an enlarged neck mass and underwent ultrasound-guided fine-needle aspiration biopsy. The most notable sonographic feature of primary thyroid lymphoma was a marked hypoechoic mass compared with the residual thyroid tissue. Among the 6 patients with a diagnosis of thyroid lymphoma, 3 (50%) had a diagnosis of lymphoma by ultrasound-guided fine-needle aspiration biopsy. Final pathologic results were obtained by ultrasound-guided core needle biopsy (3/6 patients [50%]) or thyroidectomy (3/6 [50%]). Most patients with thyroid lymphoma (5/6 [83.3%]) were found to have diffuse large B-cell lymphoma and were treated with chemotherapy with or without radiotherapy. In 1 patient with follicular lymphoma, diagnosis and treatment were accomplished by total thyroidectomy. Conclusions. Our results show that ultrasound-guided core needle biopsy can be a safe and accurate method for diagnosing thyroid lymphoma and may be a suitable replacement for diagnostic thyroid surgery.

Key Words: lymphoma • head and neck neoplasms • thyroid biopsy • thyroid neoplasm • ultrasound guidance

Abbreviations: US-CNB, ultrasound-guided core needle biopsy • US-FNAB, ultrasound-guided fine-needle aspiration biopsy




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M. J. Kim, E.-K. Kim, S. I. Park, B. M. Kim, J. Y. Kwak, S. J. Kim, J. H. Youk, and S. H. Park
US-guided Fine-Needle Aspiration of Thyroid Nodules: Indications, Techniques, Results1
RadioGraphics, November 1, 2008; 28(7): 1869 - 1886.
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Copyright © 2007 by the American Institute of Ultrasound in Medicine.