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© 2006 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 25:891-895 • 0278-4297

Experimental Study of Acute Organophosphorus Compound Poisoning in Rabbit Kidneys by Ultrasonic Tissue Characterization

Jun-Ying Cao, MD, PhD, Bao-Zhen Zhao, MD, Su-Qi Jiang, MD and Xiao-Yu Chen, MD, PhD

Department of Ultrasound, General Military Hospital of Shenyang, Shenyang, China (J.-Y.C., S.-Q.J.); and Department of Ultrasound, Chang-Hai Hospital of Second Military Medical University, Shanghai, China (B.-Z.Z., X.-Y.C.).

Address correspondence and reprint requests to Jun-Ying Cao, MD, PhD, Department of Ultrasound, General Military Hospital of Shenyang, 83 Wen-Hua Rd, Shen-He District, Shenyang 110016, China. E-mail: caojunying{at}hotmail.com

Objective. The purpose of this study was to investigate the value of integrated backscatter (IBS) of kidneys in acute organophosphorus compound poisoning in rabbits. Methods. Eighteen rabbits were poisoned by dimethyl dichlorovinyl phosphate to establish animal models. Sonographic examinations were performed before (T0) and after (T1–T9) the rabbits were poisoned. The echo and size of kidneys were evaluated by 2-dimensional gray scale sonography. Changes of the renal cortex and medulla were analyzed quantitatively with IBS. Results. No change of the cortex echo was found before and after poisoning. A significant change of the volume of kidneys on both sides began at T6 compared with that at T0 (P < .05). A significant change of renal length on both sides began at T7 compared with that at T0 (P < .05). The volume change was earlier than that of length. A significant change in IBS% of the renal cortex began at T5 compared with that at T0 (P < .05), whereas a significant change in IBS% of the renal medulla began at T6 compared with that at T0 (P < .05). The change in IBS% of the renal cortex was earlier. Conclusions. More useful information provided by IBS% has been found in acute organophosphorus compound poisoning in rabbits.

Key Words: acute organophosphorus compound poisoning • kidney • integrated backscatter • rabbits

Abbreviations: AII, average image intensity • DDVP, dimethyl dichlorovinyl phosphate • IBS, integrated backscatter

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Copyright © 2006 by the American Institute of Ultrasound in Medicine.