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© 2006 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 25:1271-1277 • 0278-4297

Sonographically Guided Percutaneous Needle Biopsy of Soft Tissue Masses With Histopathologic Correlation

Michalle Soudack, MD, Alicia Nachtigal, MD, Euvgeni Vladovski, MD, Olga Brook, MD and Diana Gaitini, MD

Departments of Medical Imaging (M.S., A.N., O.B., D.G.) and Pathology (E.V.), Rambam Medical Center, Haifa, Israel.

Address correspondence to Michalle Soudack, MD, Department of Medical Imaging, Rambam Medical Center, Ha’aliya Hashniya 8, 31096 Haifa, Israel. E-mail: m_soudack{at}rambam.health.gov.il

Objective. The purpose of this study was to evaluate the accuracy of sonographically guided percutaneous core biopsy of soft tissue masses. Methods. We retrospectively reviewed the medical records of patients who underwent sonographically guided biopsy of soft tissue masses at our institution during a 50-month period. Core biopsy histopathologic results were compared with surgical or clinical follow-up. Results. One hundred eighty-three patients, 76 male and 107 female, with a mean age of 48.5 years were included in the study. Thirteen patients had more than 1 biopsy, and the total number of biopsies performed was 196. Five patients were lost to follow-up. Biopsy results were diagnostically accurate in 174 (91%) cases. Thirteen biopsies were inconclusive. No complications occurred. The overall sensitivity, specificity, positive predictive value, and accuracy in separating malignant from benign lesions were 97%, 99%, 99%, and 98%, respectively. Conclusions. Sonographically guided core needle biopsy is an accurate and safe means to obtain tissue samples for the histopathologic diagnosis of soft tissue masses. It obviates the need for open biopsy and should be performed routinely for treatment planning.

Key Words: interventional sonography • needle biopsy • soft tissue neoplasm • sonography

Abbreviations: CT, computed tomography • FDG, fluorine-18 fluorodeoxyglucose • PET, positron emission tomography • PVNS, pigmented villonodular synovitis • SGPB, sonographically guided percutaneous biopsy

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Copyright © 2006 by the American Institute of Ultrasound in Medicine.