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© 2005 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 24:947-952 • 0278-4297

Doppler Sonographic Evaluation of Cerebral Blood Flow in Anemia Resulting From Chronic Renal Failure

Alpay Haktanir, MD, Serap Demir, MD, Murat Acar, MD, Kagan Ucok, MD, Ramazan Albayrak, MD, Aylin Yucel, MD and Cigdem Gokce, MD, MRCP

Department of Radiology, Afyon Kocatepe University Medical Faculty, Afyon, Turkey.

Address correspondence to Alpay Haktanir, MD, Afyon Kocatepe Üniversitesi Tip Fakültesi, Kirmizi Hastane, 03120 Afyon, Turkey. E-mail: dralpay{at}yahoo.com

Objective. This study was undertaken to describe Doppler sonographic measurement of cerebral blood flow in anemia secondary to chronic renal failure and to compare the results with data gathered from healthy control subjects. We also aimed to compare vertebral and internal carotid artery blood flows to see whether any alteration of dominance in cerebral blood supply would occur. Methods. We studied 27 predialytic patients with chronic anemia resulting from chronic renal failure and 20 healthy control subjects by means of extracranial Doppler sonography. In these patients, blood flows of bilateral internal carotid and vertebral arteries were measured, and net vertebral artery, net internal carotid artery, and total cerebral blood flows were estimated. Statistical significance was observed between groups, and the data were correlated with hemoglobin level. Variation of the difference of the Doppler measurements between case and control groups by side (left or right) or disease status (patient or control subject) was analyzed. Results. From the assessed Doppler parameters, only cerebral blood flow and right and net vertebral artery blood flows had a significant difference between groups (P < .05) and showed a negative correlation with hemoglobin level. Vertebral artery blood flow was found to have significant interactions with disease status (P = .009) and side (P = .054). Conclusions. Right vertebral artery blood flow is most prone to increase in chronic anemia of chronic renal failure. This effect also appears as increasing net vertebral artery blood flow and cerebral blood flow.

Key Words: blood flow volume • cerebrovascular circulation • Doppler sonography

Abbreviations: CBF, cerebral blood flow • CRF, chronic renal failure • FV, flow volume • ICA, internal carotid artery • TAV, time-averaged flow velocity • VA, vertebral artery

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Copyright © 2005 by the American Institute of Ultrasound in Medicine.