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© 2005 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 24:483-488 • 0278-4297

Correlation Between Hypoechoic Nodules on Ultrasonography and Benign Hyperplasia in the Prostatic Outer Gland

Jie Tang, MD, Xin Li, MD, Na Wang, MD, Shunxin Zhang, MD, Qian Lin, MD, Junlai Li, MD and Huaiyin Shi, MD

Departments of Ultrasound (J.T., X.L., N.W., S.Z., Q.L., J.L.) and Pathology (H.S.), Chinese People’s Liberation Army General Hospital, Beijing, China.

Address correspondence and reprint requests to Jie Tang, MD, Department of Ultrasound, Chinese People’s Liberation Army General Hospital, 28 Fuxing Rd, Beijing 100853, China. E-mail: txiner{at}vip.sina.com

Objective. The purpose of this investigation was to study the correlation between hypoechoic nodules detected on ultrasonography and benign hyperplasia in the prostatic outer gland (POG) diagnosed by transrectal ultrasonography (TRUS)-guided biopsies. Methods. The TRUS-guided biopsies were performed on 472 patients suspected of having prostate cancer. Specimens obtained by biopsies were independently assessed by pathologists at 3 hospitals. Results. The histologic results of 310 patients (65.68%) were benign. Focal hypoechoic nodules located in the POG were found in 240 patients (50.8%) on TRUS scans. Among them, in 22 patients (9.17% of the 240 patients with hypoechoic nodules), benign hyperplasia was found in focal hypoechoic nodules located in the POG. Focal nodules were seen as well circumscribed with an ovoid shape and smooth surface in 18 patients. Conclusions. Benign hyperplasia may sometimes originate in the POG and may appear as a hypoechoic nodule, similar to the appearance of prostate cancer.

Key Words: biopsy • hyperplasia • outer gland • prostate • ultrasonography

Abbreviations: CZ, central zone • PCA, prostate cancer • POG, prostatic outer gland • PSA, prostate-specific antigen • PZ, peripheral zone • TRUS, transrectal ultrasonography • TZ, transition zone

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