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Vascular Flow Patterns of Hepatic Tumors in Contrast-Enhanced 3-Dimensional Fusion Ultrasonography Using Plane Shift and Opacity Control Modes

Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan (M.O., H.K., H.T.); Department of Clinical Oncology, Medical School of Chiba University, Chiba, Japan (H.M., S.M.); and Toshiba Medical Systems Corporation, Tokyo, Japan (H.Y.).

Address correspondence and reprint requests to Masao Ohto, MD, Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. E-mail: mohto{at}qa3.so-net.ne.jp

Objective. This study was conducted to determine whether contrast-enhanced 3-dimensional (3D) fusion ultrasonography with combined use of the plane shift and opacity control modes can serve as a useful tool for identifying the vascular characteristics of hepatic tumors in 3D perspective. Methods. Contrast-enhanced 3D fusion ultrasonography was performed in 31 patients with hepatic tumors after the intravenous injection of contrast media. The shapes, courses, and distributions of tumor vessels, displayed in 3D perspective, were examined to identify the characteristic vascular flow patterns of various tumors. Images before and after contrast media administration were compared for evaluation of the effectiveness of contrast enhancement with regard to tumor diameter for various types of tumors. The images were interpreted in a blinded manner by 3 physicians specializing in abdominal ultrasonography, and vascular flow patterns were determined on the basis of consensus. Results. The characteristic vascular flow patterns observed in hepatocellular carcinomas are reticular flow within the tumor and flow showing a ringlike distribution surrounding the tumor. Metastatic tumors show a vascular flow pattern running between adjacent tumor nodules, and hemangiomas show localized nodular flow at the tumor margins. Contrast enhancement was found to be useful for showing the vascular flow patterns in small hepatocellular carcinomas and hemangiomas. Conclusions. Contrast-enhanced 3D fusion ultrasonography makes it possible to display images combining the plane shift and opacity control modes to show tumor vessels, including minute vascular flow within hepatic tumors, in 3D perspective and to identify tumor-specific vascular flow patterns.

Key Words: contrast enhancement • hepatic tumor • opacity control mode • plane shift mode • 3-dimensional fusion ultrasonography • vascular flow pattern

Abbreviations: CE, contrast-enhanced • MPR, multiplanar reconstruction • 3D, 3-dimensional • 2D, 2-dimensional • VOI, volume of interest

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