JUM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fleischer, A. C.
Right arrow Articles by Rothenberg, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fleischer, A. C.
Right arrow Articles by Rothenberg, M. E.
© 2004 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 23:1499-1506 • 0278-4297

Review Article

Sonographic Depiction of Microvessel Perfusion

Principles and Potential

Arthur C. Fleischer, MD, Kenneth J. Niermann, MD, Edwin F. Donnelly, MD, PhD, Thomas E. Yankeelov, PhD, Kathryn M. Canniff, Dennis E. Hallahan, MD and Mace E. Rothenberg, MD

Departments of Radiology (A.C.F., E.F.D.), Radiologic Oncology (D.E.H.), and Oncology (M.E.R.), Institute of Imaging Science (K.J.N., T.Y.), and Vanderbilt University Medical School (K.M.C.), Vanderbilt University Medical Center, Nashville, Tennessee USA.

Address correspondence and reprint requests to Arthur C. Fleischer, MD, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232-2675 USA. E-mail: arthur.fleischer{at}vanderbilt.edu.

Objective. To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography. Methods. Sonographic depiction of microvessel perfusion was obtained by microbubble-enhanced sonography. This technique was used for imaging in vivo murine tumors and was correlated with magnetic resonance and fluorodeoxyglucose autoradiography. Sonographic estimation of microvessel perfusion used parameters derived from time-activity curves. Results. Preliminary data indicate that accurate and reproducible quantification of microvessel perfusion is possible with the use of microbubble-enhanced sonography. Conclusions. Microbubble-enhanced sonography can depict microvessel perfusion. This technique has several potential clinical applications, including assessment of tumor blood flow and changes that occur with treatment.

Key Words: microbubble-enhanced sonography • microvessel perfusion • tumor neovascularity

Abbreviations: CDS, color Doppler sonography • CES, contrast-enhanced sonography • FDG, fluorodeoxyglucose • MR, magnetic resonance




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W.-C. Wu, J. Wang, J. A. Detre, F. W. Wehrli, E. Mohler 3rd, S. J. Ratcliffe, and T. F. Floyd
Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2129 - H2136.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
M. Krix, M.-A. Weber, H. Krakowski-Roosen, H. B. Huttner, S. Delorme, H.-U. Kauczor, and W. Hildebrandt
Assessment of Skeletal Muscle Perfusion Using Contrast-Enhanced Ultrasonography
J. Ultrasound Med., April 1, 2005; 24(4): 431 - 441.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American Institute of Ultrasound in Medicine.