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© 2004 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 23:13-17 • 0278-4297

Effects of Hypertension and Antihypertensive Treatment on Retrobulbar Circulation Detected on Doppler Sonography

M. Yasemin Karadeniz-Bilgili, MD, Yakup Ekmekci, MD, Aydin Koksal, MD, Cengiz Akarsu, MD and Ipek Ziraman, MD

Departments of Radiology (M.Y.K.-B.), Internal Medicine (Y.E., A.K.), and Ophthalmology (C.A.), Kirikkale University School of Medicine, Süleyman Demirel Hospital, Kirikkale, Turkey; and Department of Radiology, Ankara Numune Hospital, Ankara, Turkey (I.Z.).

Address correspondence and reprint requests to M. Yasemin Karadeniz-Bilgili, MD, Sevil Sokak 16/3, 06590 Cebeci, Ankara, Turkey. E-mail: mykaradeniz{at}hotmail.com.

Objective. To study the effect of antihypertensive drugs in essential hypertension and in the central retinal, posterior ciliary, and ophthalmic arteries by using Doppler sonography. Methods. Thirty patients with essential hypertension and 32 control subjects were enrolled in the study. The pulsatility and resistive indices were evaluated in the central retinal, posterior ciliary, and ophthalmic arteries before and 2 months after treatment with antihypertensive drugs as well as in the control group. The pulsatility and resistive index values for each artery in each group were compared statistically. Results. There were significant differences in the retrobulbar pulsatility and resistive index values in each artery among the patients with initially diagnosed hypertension and the control group (P < .05). There were significant reductions in the resistive and pulsatility index values of the posterior ciliary and ophthalmic arteries after treatment (P < .05). For the ophthalmic artery, posttreatment pulsatility and resistive index values did not reach the level of flow measured in the control subjects. Conclusions. The alteration of Doppler parameters of medication-free patients with hypertension may result from a peripheral vasospasm in the retrobulbar circulation, and the improvement in the Doppler parameters with oral antihypertensive drugs may indicate the importance of early diagnosis in ameliorating hypertension-induced retrobulbar circulation changes.

Key Words: antihypertensive drug • Doppler sonography • hypertension • ophthalmic artery • retrobulbar circulation

Abbreviations: ACE, angiotensin-converting enzyme • BP, blood pressure • CRA, central retinal artery • EDV, end-diastolic velocity • OA, ophthalmic artery • PCA, posterior ciliary artery • PI, pulsatility index • PSV, peak systolic velocity • RI, resistive index

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Copyright © 2004 by the American Institute of Ultrasound in Medicine.