This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soustiel, J. F. Articles by Manor, D. Search for Related Content PubMed PubMed Citation Articles by Soustiel, J. F. Articles by Manor, D.

A New Angle-Independent Doppler Ultrasonic Device for Assessment of Blood Flow Volume in the Extracranial Internal Carotid Artery

Department of Neurosurgery, Rambam (Maimonides) Medical Center, Faculty of Medicine, the Technion–Israel Institute of Technology, Haifa, Israel (J.F.S., M.Z.); Research Laboratory, Biosonix Ltd, Kfar Malal, Israel (E.L., R.B., D.M.); and Hydrodynamics Laboratory, Hull University, Hull, England (S.L.). Revised March 7, 2002. Revised manuscript accepted for publication August 15, 2002.

Address correspondence and reprint requests to Jean F. Soustiel, MD, Department of Neurosurgery, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel.

Objective. To evaluate a new angle-independent ultrasonic device for assessment of blood flow volume in the internal carotid artery. Methods. In vitro, a pulsatile pump was set to provide an outflow of physiological fluid at 500 mL/min through an 8-mm-diameter tube. Flow volume rates were measured 10 times by 10 different operators and compared with time-collected flow volume rates. In vivo, internal and common carotid artery blood flow volumes were measured in 28 volunteers by 2 operators using a FlowGuard device (Biosonix Ltd). Internal and common carotid artery diameters and blood flow volumes were also assessed by Duplex sonography and compared with FlowGuard measurements. In 10 volunteers, internal carotid artery blood flow volume changes in response to monitored breath manipulations were recorded. Results. In vitro, intraoperator variability was 4.04% (range, 2%–5.7%). The mean error rate ± SD was 3.54% ± 0.8% (range, 2.7%–5.2%). In vivo, the mean common carotid artery blood flow volume was 456 ± 39 mL/min (range, 417–583 mL/min) with a mean diameter of 6.7 ± 0.7 mm (range, 5.8–8.7 mm). The mean internal carotid artery blood flow volume was 277 ± 25 mL/min (range, 239–338 mL/min) with a mean diameter of 5 ± 0.5 mm (range, 4.1–6.1 mm). No significant difference was found between operators. Internal carotid artery diameter and blood flow volume measured by the FlowGuard were closely correlated with the results of Duplex sonography. Repeated shifts of end-tidal CO₂ induced reproducible changes in internal carotid artery flow volume: 187.5 ± 18.1 mL/min at 26.8 ± 1.9 mm Hg and 382.1 ± 18.2 mL/min at 47 ± 2.2 mm Hg. Conclusions. The FlowGuard showed that volume flow studies in the internal carotid artery could be easily performed, with results compatible with those of previous clinical reports. Duplex comparative results and breath-induced changes in internal carotid artery flow volume justify further evaluation of the system.

Key Words: cerebral blood flow • internal carotid artery • ultrasound

Abbreviations: ADBF, angle-independent dual-beam flow • BFV, blood flow volume • CCA, common carotid artery • EtCO2, end-tidal CO2 • FVR, flow volume rate • ICA, internal carotid artery

This article has been cited by other articles:

				F. Forsberg, A. D. Stein, D. A. Merton, K. J. Lipcan, D. Herzog, L. Parker, and L. Needleman Carotid Stenosis Assessed With a 4-Dimensional Semiautomated Doppler System J. Ultrasound Med., September 1, 2008; 27(9): 1337 - 1344. [Abstract] [Full Text] [PDF]

				O. Nevo, J. F. Soustiel, and I. Thaler Cerebral blood flow is increased during controlled ovarian stimulation Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3265 - H3269. [Abstract] [Full Text] [PDF]

				M. Wintermark, M. Sesay, E. Barbier, K. Borbely, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, et al. Comparative Overview of Brain Perfusion Imaging Techniques Stroke, September 1, 2005; 36(9): e83 - e99. [Abstract] [Full Text] [PDF]

				J.F. Soustiel, T.C. Glenn, P. Vespa, B. Rinsky, C. Hanuscin, and N.A. Martin Assessment of Cerebral Blood Flow by Means of Blood-Flow-Volume Measurement in the Internal Carotid Artery: Comparative Study With a 133Xenon Clearance Technique Stroke, August 1, 2003; 34(8): 1876 - 1880. [Abstract] [Full Text] [PDF]