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© 2002 by the American Institute of Ultrasound in Medicine
J Ultrasound Med 21:77-84 • 0278-4297

Pictorial Review

Hepatocellular Carcinoma

Contrast Enhancement With Levovist

Byung Ihn Choi, MD, Ah Young Kim, MD, Jae Young Lee, MD, Kyoung Won Kim, MD, Kyoung Ho Lee, MD, Tae Kyoung Kim, MD and Joon Koo Han, MD

Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital (B.I.C., K.W.K., K.H.L., J.K.H.), Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine (A.Y.K., T.K.K.), and Department of Radiology, Hallym University Hospital (J.Y.L.), Seoul, Korea

Address correspondence and reprint requests to Byung Ihn Choi, MD, Department of Radiology, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.

Objective. To present the sonographic appearance of hepatocellular carcinoma imaged with the intravenous contrast agent Levovist. Methods. We reviewed our experience using Levovist (Schering AG, Berlin, Germany) for the sonographic diagnosis of hepatocellular carcinoma. Results. Contrast-enhanced sonography with Levovist facilitated detailed evaluation of tumor vascularity in hepatocellular carcinoma. Conclusions. Contrast-enhanced sonography with Levovist enhances the role of sonography in the diagnosis of hepatocellular carcinoma. It provides detailed information about tumor vascularity and the contrast enhancement pattern.

Key Words: hepatocellular carcinoma • tumor vascularity • Doppler sonography • sonographic contrast agents

Abbreviations: ADI, agent detection imaging • AFP, {alpha}-fetoprotein • HBsAg, hepatitis B surface antigen • CD, color Doppler • CHI, coded harmonic imaging • CT, computed tomography • HCC, hepatocellular carcinoma • PD, power Doppler




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