Journal of Ultrasound in Medicine, Vol 20, Issue 6 619-627, Copyright © 2001 by American Institute of Ultrasound in Medicine

JOURNAL ARTICLE

The single umbilical artery in a high-risk patient population: what should be offered?

N. E. Budorick, T. F. Kelly, J. A. Dunn and A. L. Scioscia
Department of Radiology, University of California, San Diego, USA.

OBJECTIVE: To determine whether fetal echocardiography is warranted in cases of single umbilical artery in a population at risk for aneuploidy. METHODS: All cases of fetal single umbilical artery identified over a 2-year period were reviewed for other sonographically detected abnormalities, fetal echocardiographic results, and karyotype. RESULTS: Sixty-five cases of single umbilical artery were diagnosed on the basis of initial sonograms. Five were subsequently shown to have 3-vessel cords (8% false-positive diagnosis; incidence, 1.2%). Excluding 3 from twin gestations, 57 cases formed the study population. Thirty-one fetuses (54%) were initially thought to have isolated single umbilical arteries, and 26 (46%) had nonisolated single umbilical arteries. Fetal echocardiography was performed in 29 cases (51%), 24 (83%) with normal findings and 5 (17%) with abnormal findings. Four (50%) of 8 nonisolated single umbilical arteries had abnormal echocardiographic findings versus 1 (5%) of 21 apparently isolated single umbilical arteries (P < .05; odds ratio, 20). Karyotypes in 36 cases (63%) showed 25 (69%) euploid and 11 (31%) aneuploid fetuses. An apparently isolated single umbilical artery was never associated with an abnormal karyotype. Eleven (50%) of 22 fetuses with nonisolated single umbilical arteries had aneuploidy (P < .005). The side of the missing umbilical artery did not correlate with other sonographically detected abnormalities, abnormal fetal echocardiographic findings, or aneuploidy. CONCLUSIONS: The rate of cardiac malformations seen with apparently isolated single umbilical arteries is significant, and fetal echocardiography should be performed.

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				D. R. Gossett, M. E. Lantz, and C. A. Chisholm Antenatal Diagnosis of Single Umbilical Artery: Is Fetal Echocardiography Warranted? Obstet. Gynecol., November 1, 2002; 100(5): 903 - 908. [Abstract] [Full Text] [PDF]