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Journal of Ultrasound in Medicine, Vol 20, Issue 5 451-458, Copyright © 2001 by American Institute of Ultrasound in Medicine
Spiral computed tomographic imaging related to computerized ultrasonographic images of carotid plaque morphology and histology
M. L. Gronholdt, A. Wagner, B. M. Wiebe, J. U. Hansen, T. V. Schroeder, J. E. Wilhjelm, M. Nowak and H. Sillesen
Department of Vascular Surgery, Rigshospitalet, Copenhagen, Denmark.
OBJECTIVE: Echolucency of carotid atherosclerotic plaques, as evaluated by
computerized B-mode ultrasonographic images, has been associated with an
increased incidence of brain infarcts on cerebral computed tomographic
scans. We tested the hypotheses that characterization of carotid plaques on
spiral computed tomographic images correlates with that on computerized
B-mode ultrasonographic images and that spiral computed tomographic imaging
predicts the histomorphometric plaque content. METHODS: The study included
38 patients with neurologic symptoms and at least 50% stenosis of the
ipsilateral carotid artery. High-resolution B-mode ultrasonographic images
and spiral computed tomographic images of carotid plaques were computer
processed to yield a quantitative measure, the gray scale level of the
plaque. RESULTS: The mean Hounsfield value for spiral computed tomographic
images correlated with the gray scale median for B-mode ultrasonographic
images (univariate linear regression analysis: r = 0.45; P = .01) and the
histologic content of calcification in the plaque (r = 0.34; P = .04) but
not with lipid, hemorrhage, or fibrous tissue in the plaque. CONCLUSIONS:
Spiral computed tomographic imaging seems to correlate with B-mode
ultrasonographic imaging for showing plaque characteristics. Spiral
computed tomographic attenuation was also correlated with the amount of
calcification noted on histologic examination but not with lipid and
hemorrhage, the components thought to characterize vulnerable,
rupture-prone plaques.
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