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Journal of Ultrasound in Medicine, Vol 19, Issue 1 55-61, Copyright © 2000 by American Institute of Ultrasound in Medicine
Sonographic depiction of tumor vascularity and flow: from in vivo models to clinical applications
A. C. Fleischer
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2675, USA.
This review discusses and illustrates the sonographic depiction and
quantification of tumor vascularity and flow using three-dimensional color
Doppler sonography. The potential clinical applications mentioned here are
based on work done with in vivo tumor models and as well as extensive
clinical experience with this technique. Three-dimensional color Doppler
sonography, as used with contrast agents and novel imaging techniques, has
significant current and potential clinical application for detailed
depiction of tumor vascularity and flow. This technique can provide
important information concerning changes in tumor vascularity and flow
related to various biologic, chemical, and radiation therapies as
demonstrated in animals and a few human studies. Additional animal and
human studies are needed for further refinement and eventual clinical
application of this technique.
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