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Journal of Ultrasound in Medicine, Vol 15, Issue 2 127-134, Copyright © 1996 by American Institute of Ultrasound in Medicine
Color amplitude imaging: preliminary results using vascular sonographic contrast agents
B. B. Goldberg, D. A. Merton, F. Forsberg, J. B. Liu and N. Rawool
Department of Radiology, Thomas Jefferson Universtiy Hospital, Jefferson Ultrasound research and Education Institute, Philadelphia, Pennsylvania 19107- 5244, USA.
Conventional (mean Doppler frequency shift) color Doppler imaging and a new
method of displaying blood flow in color that uses the amplitude of the
Doppler signal were utilized to evaluate three vascular sonographic
contrast agents. To compare the two color flow detection modalities, a
total of 20 pairs of contrast agent injections were performed while imaging
a variety of abdominal organs and tumors in experimental animal models. The
20 paired injections were scored independently to indicate whether color
amplitude imaging better demonstrated the effects of contrast enhancement
(n = 14), both techniques were equivalent in demonstrating the effects of
contrast enhancement (n = 4), or color Doppler imaging better demonstrated
the effects of contrast enhancement (n = 2). These results indicate that
compared to color Doppler imaging, color amplitude imaging improved
visualization of both normal and abnormal blood flow in 70% of these cases
(P < 0.0001). Specifically, with contrast enhancement of the Doppler
signals, organ vascularity and regional differences in parenchymal blood
flow were better demonstrated with color amplitude imaging than with color
Doppler imaging. In addition, since color amplitude imaging is
nondirectional and less angle dependent than color Doppler imaging, it was
possible to visualize vessel continuity more completely and to demonstrate
vessel branching more clearly with this modality. However, owing to the
lack of directivity and poor temporal resolution, information obtained with
color amplitude imaging appears to be complementary to that of color
Doppler imaging. In conclusion, color amplitude imaging is a reliable
method of determining the effectiveness of vascular sonographic contrast
agents and should be considered one of the primary flow imaging modalities
used for the assessment of these agents.
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