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Journal of Ultrasound in Medicine, Vol 13, Issue 6 443-450, Copyright © 1994 by American Institute of Ultrasound in Medicine


JOURNAL ARTICLE

Intravascular platelet aggregation and spontaneous contrast

C. Mahony, C. Spain, M. Spain, J. Evans, J. Ferguson and M. D. Smith
Division of Cardiology, University of Kentucky Medical Center, Lexington 40536-0084.

The purpose of this study was to determine why spontaneous contrast developed after general anesthesia in dogs. Twenty-seven dogs underwent echocardiography before and after pentobarbital or chloralose-urethane general anesthesia. The results showed that none of the 12 dogs receiving pentobarbital and 10 of 15 dogs receiving chloralose-urethane anesthesia developed contrast, in association with large platelet and platelet-neutrophil aggregates (P < 0.01); this effect could also be reproduced in vitro. The administration of adenosine diphosphate or antiplatelet antibody to nine dogs confirmed that intravascular platelet aggregation can cause ultrasonic contrast. The implications of these findings for patients with spontaneous contrast are discussed.


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Copyright © 1994 by the American Institute of Ultrasound in Medicine.