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Journal of Ultrasound in Medicine, Vol 13, Issue 4 295-301, Copyright © 1994 by American Institute of Ultrasound in Medicine

CLINICAL TRIAL

An attempt to screen asymptomatic women for ovarian and endometrial cancer with transvaginal color and pulsed Doppler sonography

A. Kurjak, H. Shalan, S. Kupesic, D. Kosuta, A. Sosic, S. Benic, M. Ilijas, S. Jukic and M. Predanic
Ultrasonic Institute, Medical School, University of Zagreb Sveti Duh Hospital, Croatia.

Several screening procedures have been proposed to detect ovarian and endometrial cancer. However, none of them is sensitive and specific enough to be used in population-based screening programs. During our 5 year long study, 5013 asymptomatic women (44% premenopausal and 56% postmenopausal women) were scanned by transvaginal color and pulsed Doppler ultrasonography in an attempt to detect malignancy. These women had 404 adnexal cysts; 70 had resolved spontaneously on follow-up scans and 18 persisted. Another 316 sonographically benign cysts are still in the procedure of follow-up second scans. Of 5013 women, four women had stage I ovarian carcinoma and six had stage I endometrial carcinoma. There was one false-positive case encountered with an endometrioma. Only 14 women were subjected to major operative intervention; others underwent minor procedures based on the benign scan findings. No medical or surgical complications were reported. Transvaginal color Doppler ultrasonography, a noninvasive procedure, can detect ovarian and endometrial carcinoma in asymptomatic women and may be used as a screening procedure for these diseases.


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Copyright © 1994 by the American Institute of Ultrasound in Medicine.