Journal of Ultrasound in Medicine, Vol 13, Issue 12 937-943, Copyright © 1994 by American Institute of Ultrasound in Medicine

JOURNAL ARTICLE

Significance of orbital measurements in the fetus

T. Trout, N. E. Budorick, D. H. Pretorius and J. P. McGahan
Department of Radiology, University of California, San Diego.

Orbital imaging is not performed routinely during obstetrical sonography, but the discovery of abnormal orbital diameters provides evidence of fetal dysgenesis. This study was designed to establish the validity of a previously developed orbital nomogram for a high-risk population and to determine whether proved cases of hypotelorism and hypertelorism fell outside the normal ranges. Inner and outer orbital measurements of 422 fetuses were obtained prospectively during routine obstetrical sonography in a high-risk patient population. Comparison of these measurements to the previously established nomogram demonstrated that the nomogram is still accurate with current equipment and in a population at high risk for anomalies. In addition, sonograms and autopsy and clinical data from six cases of hypotelorism, two of cyclopia, and three of hypertelorism were reviewed retrospectively. Both inner and outer orbital measurements fell clearly below two standard deviations of the mean in all six cases of hypotelorism. The three cases of hypertelorism had inner orbital measurements above the 95th percentile and outer orbital distances within normal limits but near the 95th percentile. All cases with abnormal orbital distances had associated intra- or extracranial abnormalities, including holoprosencephaly, encephalocele, cleft palate, cardiac anomalies, imperforate anus, diaphragmatic hernia, and digit anomalies.

This article has been cited by other articles:

				P. Rosati and L. Guariglia Early Transvaginal Fetal Orbital Measurements: A Screening Tool for Aneuploidy? J. Ultrasound Med., November 1, 2003; 22(11): 1201 - 1205. [Abstract] [Full Text] [PDF]