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Journal of Ultrasound in Medicine, Vol 13, Issue 10 767-775, Copyright © 1994 by American Institute of Ultrasound in Medicine

CLINICAL TRIAL

Fetal biometry of skeletal dysplasias: a multicentric study

L. Goncalves and P. Jeanty
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee.

Twenty-three diagnostic centers worldwide contributed 127 cases of 17 skeletal dysplasias. Discriminant analysis showed that the femur length was the best biometric parameter to distinguish among the five most common disorders in this series (thanatophoric dysplasia, osteogenesis imperfecta type II, achondrogenesis, achondroplasia and hypochondroplasia). Fifty-four percent of fetuses with femur length below 30% of the mean for gestational age had achondrogenesis. Seventy-eight percent of measurements between 40 and 60% of the mean for gestational age represented either thanatophoric dysplasia or osteogenesis imperfecta type II. Fetuses who had over 80% of the mean for gestational age had predominantly hypochondroplasia, achondroplasia, and osteogenesis imperfecta type III.




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Copyright © 1994 by the American Institute of Ultrasound in Medicine.