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Journal of Ultrasound in Medicine, Vol 12, Issue 5 275-280, Copyright © 1993 by American Institute of Ultrasound in Medicine
Ultrasonographic evaluation of the endometrium and correlation with endometrial sampling in postmenopausal patients treated with tamoxifen
I. Cohen, D. J. Rosen, R. Tepper, M. Cordoba, Y. Shapira, M. M. Altaras, D. Yigael and Y. Beyth
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.
Seventy-two asymptomatic, postmenopausal women treated with tamoxifen for
breast cancer were studied prospectively with vaginal ultrasonography,
followed by endometrial sampling. Seventy-one patients demonstrated an
endometrial echo of more than 5 mm, and one displayed an endometrial echo
of less than 5 mm. No patient with an endometrial echo of less than 5 mm
displayed any endometrial pathology. Different endometrial pathologic
conditions were found when the endometrial echo was over 5 mm. When
classifying those patients whose ultrasonic endometrial widths were wider
than 5 mm, on the basis of different endometrial histologic findings, no
obvious correlation was found between the various pathologic endometrial
findings and endometrial thickness. Thus, a "thicker" endometrial
sonographic image did not necessarily correlate with pathologic endometrial
findings. When ultrasonic endometrial thickness of 5 mm was considered the
upper limit of normal, the sensitivity of ultrasonography in correlating to
positive histologic findings was 91% and the specificity was 96%. These
findings suggest that there is good correlation between endometrial width
measured by ultrasonographic assessment and histologic findings.
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