Journal of Ultrasound in Medicine, Vol 11, Issue 3 65-68, Copyright © 1992 by American Institute of Ultrasound in Medicine
The effect of intravenous furosemide on the Doppler waveform in normal kidneys
S. A. Renowden and D. L. Cochlin
Department of Diagnostic Radiology, University Hospital of Wales, College of Medicine, Cardiff.
Duplex Doppler sonography is currently being evaluated in the
differentiation of obstructive and nonobstructive hydronephrosis. It was
thought that this method may be of use in the diagnosis and follow-up of
pelviureteric junction obstruction, and that its sensitivity may be
increased by the use of intravenous furosemide to raise the intrarenal
pressure in obstructive cases. Before embarking on a formal study, a pilot
study was initiated to determine the effect of furosemide on the Doppler
waveform of the normal kidney. Intravenous furosemide had variable effects
on peak systolic and end-diastolic velocities and little significant effect
on resistive index but caused a constant and dramatic subjective increase
in vascularity. Possible modes of action are discussed.
