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Journal of Ultrasound in Medicine, Vol 10, Issue 12 665-670, Copyright © 1991 by American Institute of Ultrasound in Medicine

JOURNAL ARTICLE

Sister chromatid exchange analysis of human cells exposed to diagnostic levels of ultrasound

A. O. Martin, E. L. Madsen, A. R. Dyer, L. White, N. P. Bouck, R. E. Sabbagha, M. Hermanoff, J. M. Chen and L. J. Ludtke
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois.

Lymphocyte and lymphoblastoid cells were exposed in vitro to diagnostic levels of ultrasonic beams delivered by a Hewlett-Packard CE 30001 and a GE system with a 5 MHz linear transducer for 20 sec, 1 min, 5 min, and 20 min. Temperature and cavitation effects were controlled and there were matched sham exposures. The synergistic effects of theophylline with ultrasonography also were investigated. Small increases in sister chromatid exchange levels were observed after ultrasonic exposure, but increases were so small as to be unlikely to have clinical relevance. Theophylline was found to have no effect and ultrasonography had no effect on cell viability.




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Copyright © 1991 by the American Institute of Ultrasound in Medicine.